Epidermal insulin resistance as a therapeutic target in acanthosis nigricans?
نویسندگان
چکیده
منابع مشابه
Comparison of Insulin resistance in obese women with and without Acanthosis Nigricans
Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of AN. In this study insulin resistance was compared in obese women with and without AN.</sp...
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FGFR3 mutations cause wide spectrum of disorders ranging from skeletal dysplasias (hypochondroplasia, achondroplasia, and thanatophoric dysplasia), benign skin tumors (epidermal nevi, seborrhaeic keratosis, and acanthosis nigricans), and epithelial malignancies (multiple myeloma and prostate and bladder carcinoma). Hypochondroplasia is the most common type of short-limb dwarfism in children res...
متن کاملAssociation of acanthosis nigricans and skin tags with insulin resistance.
Insulin resistance is a metabolic disorder in which target cells fail to respond to normal levels of circulating insulin. Insulin resistance has been associated with presence of acanthosis nigricans and acrochordons. It is known that early diagnosis and early initial treatment are of paramount importance to prevent a series of future complications. These dermatoses may represent an easily ident...
متن کاملCorrelation between acanthosis nigricans and insulin resistance in obese children in Manado
Methods We performed a cross sectional analytic observational study. One hundred twenty three obese children, ages 10 – 14 years with and without acanthosis nigricans got examined for insulin resistance using Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR). Diagnosis of acanthosis nigricans is confirmed by a dermatologist. This study took place in Wenang district, Manado, Nor...
متن کاملAcanthosis nigricans in obese Chinese children.
OBJECTIVES. To investigate the demographic characteristics and insulin resistance in local overweight/obese Chinese children with and without acanthosis nigricans, and the associations of acanthosis nigricans with insulin resistance and other cardiometabolic co-morbidities. DESIGN. Case series with cross-sectional analyses. SETTING. A regional hospital in Hong Kong. PATIENTS. Chinese children a...
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عنوان ژورنال:
- Acta dermato-venereologica
دوره 94 5 شماره
صفحات -
تاریخ انتشار 2014